Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC
نویسندگان
چکیده
منابع مشابه
Overexpression and amplification of Aurora-A in hepatocellular carcinoma.
PURPOSE Aurora-A/STK15/BTAK, a centrosome-associated serine/threonine kinase, has been shown to induce chromosomal instability, leading to aneuploidy and cell transformation. The purpose of this study was to investigate the expression and amplification of Aurora-A in hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN Aurora-A mRNA levels were measured in 224 HCCs and 199 paired nontumorous l...
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متن کاملAurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation.
Alterations in chromosome number (aneuploidy) are common in human neoplasias. Loss of mitotic regulation is believed to induce aneuploidy in cancer cells and act as a driving force during the malignant progression. The serine/theronine protein kinases of aurora family genes play a critical role in the regulation of key cell cycle processes. Aurora B mediates chromosome segregation by ensuring o...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2010
ISSN: 1471-2407
DOI: 10.1186/1471-2407-10-461